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5-HTP, also known as 5-hydroxytryptophan, is the direct precursor to the neurotransmitter serotonin. Low levels of serotonin are associated with sleep problems, depression, anxiety, compulsive
eating disorders, restless leg syndrome, migraines, fibromyalgia and low pain threshold. Many people that are afflicted with one of those conditions often have others, which has led some
researchers to label them collectively as "Low Serotonin Syndrome.
Serotonin is an important initiator of sleep. In numerous studies 5-HTP has been shown to decrease the time required to get to sleep and to decrease the number of awakening. It also increases
REM sleep and deep sleep.
By increasing the brain’s concentration of serotonin, an antidepressant effect is created. 5-HTP works by increasing the amount of serotonin manufactured in the brain. Although systematically
administered serotonin does not readily enter the brain, its direct precursor, 5-HTP does penetrate the blood-brain barrier, and therefore, dietary consumption of 5-HTP leads to an increase in
brain serotonin concentration.
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